Holiday Inn Express & Suites St. Louis South I 55 by IHG

4250 Midamerica Lane, St. Louis, MO 63129 US near Exit 195 on I-55 (~0.1mi)
View Map Reservations: +1-800-219-2797
2.5 Star Property Near Barnes Jewish South Campus
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Select My Room
  • Wheelchair-accessible pool
  • Free WiFi
  • Number of indoor pools - 1
  • Stair-free path to entrance
  • 24-hour fitness facilities
  • Free buffet breakfast
  • Free breakfast
  • Smoke-free property
  • Free self parking
Select Your Room:
07/28/2026 - 07/29/2026
Searching all hotel inventory networks
7 bookings in the last 48 hours

Standard prices by room type for the next 60 days

Rates shown are nightly rates before taxes and do not necessarily reflect all discounts available. The chart provides the cheapest public rates available by room type.

Verified Reviews of Holiday Inn Express & Suites St. Louis South I 55 by IHG

Below are the verified reviews from guests that we have booked recently:
"Tailor at the front desk is great"
Overall Score5.0/ 5
Clean room Great staff.
(Individual traveler, booked 1 room), from US flag
16-May-2026 Verified Review, stayed from Thu May 14 to Sun May 17 2026 at a $183.00 average nightly rate.
"Very clean room respectful friendly staff and better than than the usual hotel breakfast"
Overall Score5.0/ 5
Excellant
(Individual traveler, booked 1 room), from US flag
01-Apr-2026 Verified Review, stayed from Tue Mar 31 to Wed Apr 01 2026 at a $183.33 average nightly rate.
"Great place"
Overall Score5.0/ 5
We stayed for one night. Had warm cookies when we arrived. Rooms were clean and big. Breakfast was good.
(Group coordinator, booked 2 rooms), from US flag
11-Jan-2026 Verified Review, stayed from Sat Jan 10 to Sun Jan 11 2026 at a $109.99 average nightly rate.
"Very clean very hospitable people that worked there overall great experience"
Overall Score5.0/ 5
I would recommend anybody who wants to go to a very nice clean good hotel with a great breakfast to Holiday Inn express.
(Individual traveler, booked 1 room), from US flag
23-Nov-2025 Verified Review, stayed from Sat Nov 22 to Sun Nov 23 2025 at a $141.99 average nightly rate.
"Great place to stay."
Overall Score5.0/ 5
We arrived late and Hailey was at the front desk. She was so nice and helpful. Very personable. The bed was very comfortable and our room was very clean.
(Individual traveler, booked 1 room), from US flag
30-Sep-2025 Verified Review, stayed from Sat Sep 27 to Sun Sep 28 2025 at a $181.46 average nightly rate.
"Great Experience"
Overall Score5.0/ 5
This was a very clean and quiet hotel. Good breakfast in the morning.
(Individual traveler, booked 1 room), from US flag
15-Sep-2025 Verified Review, stayed from Fri Sep 12 to Sat Sep 13 2025 at a $170.00 average nightly rate.
"Relaxing"
Overall Score5.0/ 5
Friendly staff and clean accommodations.
(Individual traveler, booked 1 room), from US flag
14-Jul-2025 Verified Review, stayed from Fri Jul 11 to Mon Jul 14 2025 at a $152.00 average nightly rate.
"Great staff, clean, quiet."
Overall Score5.0/ 5
We stayed at this Holiday Inn because it was located next door to a medical facility where my husband had appointments. It was a great stay, I woudn’t hesitate to stay here again. The staff was extremely helpful, the room was spotless and the hotel was quiet, even tho there were a lot of people staying there. In the evening they put out warm cookies and milk. Would definitely recommend !
(Individual traveler, booked 1 room), from US flag
07-Jul-2025 Verified Review, stayed from Tue Jul 01 to Wed Jul 02 2025 at a $143.99 average nightly rate.
"Front desk personnel very nice and helpful."
Overall Score5.0/ 5
Facility very clean, good parking, nice large room. Loved the cookies in the evening. Very nice breakfast. We always try to book Holiday Inn when we travel because their standards are consistent. We know there services will be very good.
(Individual traveler, booked 1 room), from US flag
12-Jun-2025 Verified Review, stayed from Thu Jun 12 to Fri Jun 13 2025 at a $143.99 average nightly rate.
"Wonderful place to stay."
Overall Score5.0/ 5
Very clean hotel. Staff is great. Can’t think of anything bad about this place!
(Individual traveler, booked 1 room), from US flag
14-May-2025 Verified Review, stayed from Tue May 13 to Thu May 15 2025 at a $169.00 average nightly rate.
"Wonderful!"
Overall Score5.0/ 5
Everything about this hotel is great. Clean, nicely furnished rooms, friendly and helpful staff, good breakfast.
(Individual traveler, booked 1 room), from US flag
02-May-2025 Verified Review, stayed from Sun Apr 27 to Wed Apr 30 2025 at a $130.00 average nightly rate.
"Better Than Excellent 7 of of 7."
Overall Score5.0/ 5
The room I got had a bed that too high for me to get into as I am disabled. I called the front desk, to see if the had a step stool. Julie at the front desk said no that it was a safety protocol but they did have Physical Handicap Room availiable with a walk in shower and a lower bed at no extra charge. The room was very large and really nice. The bed was much lower which I could easily get into. The walk in shower was great, no step at all and with the hand rails taking a shower was very easy and safe. Next time I'm in St. Louis, I hope this room is available, it made my stay so much more delightful. Even better, the free breakfast! Oh man I was in heaven. They have a "Pancake Maker" that makes the best pancakes you've ever tasted. They also have a sausage gravy that you must try, it's fantastic! Even better, at 8 pm they serve Free cookies, mouth watering chocolate chip cookies that are out of this world great! The staff was very friendly and bent over backwards to make my stay all that much better. Did I say 7 of 7, I meant 10 of 10!
(Individual traveler, booked 1 room), from US flag
13-Mar-2025 Verified Review, stayed from Tue Mar 11 to Thu Mar 13 2025 at a $177.49 average nightly rate.
"Very Nice Hotel"
Overall Score5.0/ 5
Very nice hotel.
(Individual traveler, booked 1 room), from US flag
13-Mar-2025 Verified Review, stayed from Tue Mar 11 to Thu Mar 13 2025 at a $153.99 average nightly rate.
"Awesome Rooms!"
Overall Score5.0/ 5
Room was clean and very large, breakfast was very good. Would stay there again.
(Individual traveler, booked 1 room), from US flag
10-Feb-2025 Verified Review, stayed from Fri Feb 07 to Sat Feb 08 2025 at a $125.00 average nightly rate.

Summary of Verified Reviews

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Property Description

Located in St. Louis, Holiday Inn Express & Suites St. Louis South - I-55 by IHG is in the business district, within a 5-minute drive of Barnes Jewish South Campus and BounceU of St. Louis. This hotel is 12.4 mi (20 km) from Forest Park and 13.4 mi (21.5 km) from St. Louis Zoo.

A complimentary buffet breakfast is served daily from 6:00 AM to 9:30 AM.

Make yourself at home in one of the 99 guestrooms featuring refrigerators and flat-screen televisions. Complimentary wired and wireless internet access keeps you connected, and cable programming provides entertainment. Private bathrooms have complimentary toiletries and hair dryers. Conveniences include safes and desks, as well as phones with free local calls.

Distances are displayed to the nearest 0.1 mile and kilometer.

Barnes Jewish South Campus - 0.6 km / 0.3 mi
BounceU of St. Louis - 4 km / 2.5 mi
St Anthony's - 4.6 km / 2.8 mi
Suson Park - 5 km / 3.1 mi
Kindred Hospital St. Louis South - 5 km / 3.1 mi
Meramec River - 5.2 km / 3.2 mi
Mercy Hospital South - 7.4 km / 4.6 mi
Sylvan Springs County Park - 7.4 km / 4.6 mi
Jefferson Barracks National Cemetery - 8.4 km / 5.2 mi
Arnold Historical Society & Museum - 8.4 km / 5.2 mi
Jefferson Barracks Historic Park - 8.7 km / 5.4 mi
Missouri Civil War Museum - 9 km / 5.6 mi
Ulysses S. Grant National Historic Site - 9.7 km / 6 mi
Grant's Farm - 9.7 km / 6 mi
River des Peres Greenway Trailhead - 12.3 km / 7.6 mi

The nearest airports are:
St. Louis Lambert Intl. Airport (STL) - 42 km / 26.1 mi
St. Louis, MO (SUS-Spirit of St. Louis) - 42.2 km / 26.2 mi

Featured amenities include a business center, a 24-hour front desk, and a safe deposit box at the front desk. Free self parking is available onsite.

Be sure to enjoy recreational amenities including an indoor pool and a 24-hour fitness center. Additional features at this hotel include complimentary wireless internet access, a banquet hall, and a vending machine.

Green Sustainability

Yes, ask the front desk about our Greener Stay program

Amenities / Features

  • Check In: 3:00 PM
  • Check Out: 11:00 AM
  • Minimum age of oldest guest: 21
  • Wheelchair accessible (may have limitations)
  • Banquet hall
  • Wheelchair-accessible concierge desk
  • Vending machine
  • Wheelchair-accessible van parking
  • No single-use plastic straws
  • Wheelchair-accessible path to elevator
  • Meeting rooms
  • Change of bed sheets (on request)
  • Wheelchair-accessible fitness center
  • Wheelchair-accessible pool
  • Free WiFi
  • Wheelchair-accessible public washroom
  • Well-lit path to entrance
  • Change of towels (on request)
  • Number of indoor pools - 1
  • Stair-free path to entrance
  • Total number of rooms - 99
  • Number of floors - 4
  • Professional property host/manager
  • LGBTQIA+ friendly
  • Wheelchair accessible parking
  • 24-hour fitness facilities
  • Free buffet breakfast
  • Wheelchair-accessible lounge
  • Free breakfast
  • Visual alarms in hallways
  • Business center
  • 24-hour front desk
  • Daily
  • Housekeeping on request
  • Smoke-free property
  • Safe-deposit box at front desk
  • Free self parking
  • Elevator
  • Pool sun loungers
  • Wheelchair accessible path of travel
  • Sustainability/community reinvestment (10% revenue or more)

Airport & Shuttle Information

Lambert International Airport, 22 miles, $40 taxi

Airport Shuttle? Sorry, no airport shuttle available.

Breakfast Information

Express Start Breakfast is a full, hot buffet, included in all room rates. Make-your-own pancakes, serve up some eggs, meats, biscuits & gravy, oatmeal, cold cereal, yogurt, and much more!

Pet Friendly?

Service animals complying with ADA Title lll regulations are allowed.

Service animals are allowed

Service animals are exempt from fees/restrictions

Pets not allowed

No pets allowed, service animals ONLY

Parking Info

Free, self-parking, on our surface lot, with plenty of room for buses, trucks, and trailers.

Internet / WiFI

FREE WiFi, wired & wireless, throughout the building

Cleaning Policies

Contactless check-out is available

Property follows a brand or regulatory agency's sanitization guidelines Clean Promise (IHG)

Essential workers only - NO

About Holiday Inn Express

  • Free Express Start Breakfast
  • Have their own 100% Arabica Smart Roast Coffee
  • Free high-speed internet service in every room
  • eHost Online Concierge Service where guests can learn about hotel amenities, major airlines nearby, up-to-date local weather and even car rental services
  • Perfect for the business traveler on the go, Holiday Inn Express offers 24/7 hours & photocopy services

The Holiday Inn Express highlights above are subject to change without notice.

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