21c Museum Hotel Louisville

700 W Main Street, Louisville, KY 40202 US near Exit 4 on I-64 (~0.2mi)
View Map Reservations: +1-800-219-2797
4.5 Star Property Near Louisville Slugger Museum
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Select Your Room:
07/28/2026 - 07/29/2026
Searching all hotel inventory networks
9 bookings in the last 48 hours

Standard prices by room type for the next 60 days

Rates shown are nightly rates before taxes and do not necessarily reflect all discounts available. The chart provides the cheapest public rates available by room type.

Verified Reviews of 21c Museum Hotel Louisville

Below are the verified reviews from guests that we have booked recently:
"Great location"
Overall Score5.0/ 5
We really enjoyed staying here. Everything was great.
(Individual traveler, booked 1 room), from US flag
24-May-2026 Verified Review, stayed from Fri May 15 to Tue May 19 2026 at a $321.50 average nightly rate.
"Lovely hotel"
Overall Score4.0/ 5
We enjoyed our stay at 21c Museum Hotel. Only wish we would have had a better view. But, that is just a minor note. Everything else was perfect!
(Individual traveler, booked 1 room), from US flag
02-Jan-2026 Verified Review, stayed from Thu Jan 01 to Fri Jan 02 2026 at a $139.00 average nightly rate.
"Staff was great especially at check-in."
Overall Score5.0/ 5
Staff was great especially at check-in.
(Individual traveler, booked 1 room), from US flag
18-Sep-2025 Verified Review, stayed from Sun Sep 14 to Mon Sep 15 2025 at a $243.67 average nightly rate.
"Great Staff"
Overall Score5.0/ 5
Everyone was very helpful and we required a lot!
(Individual traveler, booked 1 room), from US flag
07-Sep-2025 Verified Review, stayed from Sat Sep 06 to Sun Sep 07 2025 at a $288.15 average nightly rate.
"Clean, great location to walk plus great bar and restaurant."
Overall Score5.0/ 5
So much to do and right in center of downtown loved it!
(Individual traveler, booked 1 room), from US flag
13-Aug-2025 Verified Review, stayed from Mon Aug 11 to Wed Aug 13 2025 at a $111.99 average nightly rate.
"Excellent Stay!"
Overall Score5.0/ 5
Hotels is right in the middle of downtown, walking distance to where you want to go. Staff and rooms were incredible. I’ll definitely be back.
(Group coordinator, booked 2 rooms), from US flag
21-Jun-2025 Verified Review, stayed from Tue Jun 17 to Thu Jun 19 2025 at a $207.20 average nightly rate.

Summary of Verified Reviews

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Property Description

With a stay at 21c Museum Hotel Louisville, you'll be centrally located in Louisville, steps from Louisville Slugger Museum and 8 minutes by foot from Kentucky International Convention Center. This luxury hotel is 0.4 mi (0.7 km) from KFC Yum Center and 0.4 mi (0.7 km) from Fourth Street Live!.

Grab a bite to eat at Proof on Main, a fine-dining restaurant which features a bar/lounge, or stay in and take advantage of the room service (during limited hours). Full breakfasts are served on weekdays from 7:00 AM to 10:00 AM and on weekends from 8:00 AM to 1:00 PM for a fee.

Make yourself at home in one of the 91 guestrooms featuring iPod docking stations and minibars. Your bed comes with down comforters and premium bedding. Wired and wireless internet access is complimentary, while 50-inch LCD televisions with cable programming provide entertainment. Private bathrooms have designer toiletries and hair dryers.

Distances are displayed to the nearest 0.1 mile and kilometer.

Ohio River Valley - 0.1 km / 0.1 mi
21c Museum Hotel - 0.1 km / 0.1 mi
Louisville Science Center - 0.1 km / 0.1 mi
Evan Williams Bourbon Experience - 0.2 km / 0.1 mi
Kentucky Center for the Performing Arts - 0.2 km / 0.1 mi
Louisville Slugger Museum - 0.2 km / 0.2 mi
Muhammad Ali Center - 0.3 km / 0.2 mi
Frazier International History Museum - 0.3 km / 0.2 mi
Kentucky Bourbon Trail Visitor Center - 0.4 km / 0.2 mi
Riverfront Plaza Belvedere - 0.5 km / 0.3 mi
Actors Theatre of Louisville - 0.6 km / 0.4 mi
Kentucky International Convention Center - 0.7 km / 0.4 mi
KFC Yum Center - 0.7 km / 0.4 mi
Fourth Street Live! - 0.7 km / 0.4 mi
Whiskey Row - 0.8 km / 0.5 mi

The nearest airports are:
Louisville Intl. Airport (SDF) - 11.4 km / 7.1 mi
Louisville, KY (LOU-Bowman Field) - 13.1 km / 8.1 mi

The preferred airport for 21c Museum Hotel Louisville is Louisville Intl. Airport (SDF).

Featured amenities include complimentary wired internet access, a 24-hour business center, and limo/town car service. Planning an event in Louisville? This hotel has 5000 square feet (465 square meters) of space consisting of conference space and meeting rooms.

Relax at the full-service spa, where you can enjoy massages. Additional features at this hotel include complimentary wireless internet access, concierge services, and gift shops/newsstands.

Amenities / Features

  • Check In: 4:00 PM
  • Check Out: 11:00 AM
  • Minimum age of oldest guest: 21
  • Dry cleaning/laundry service
  • Gift shops or newsstand
  • Eco-friendly cleaning products used
  • Biodegradable/compostable stirrers
  • No single-use plastic straws
  • No single-use plastic soda bottles
  • No single-use plastic stirrers
  • Conference space size (meters) - 465
  • Reusable cups only
  • Reusable tableware only
  • Free wired internet
  • Biodegradable/compostable straws
  • Limo or town car service available
  • No single-use plastic water bottles
  • Free WiFi
  • Number of bars/lounges - 1
  • Braille or raised signage
  • Assistive listening devices available
  • Wheelchair accessible parking
  • Tours/ticket assistance
  • Comprehensive food waste policy
  • Eco-friendly toiletries
  • At least 80% of all lighting comes from LEDs
  • Eco-friendly cleaning products provided
  • LED light bulbs
  • Vegan menu options available
  • Multilingual staff
  • Electric car charging station
  • Breakfast available (surcharge)
  • Coffee/tea in common areas
  • Laundry facilities
  • Elevator
  • Year Built - 2006
  • Number of buildings/towers - 1
  • Total number of rooms - 91
  • Number of floors - 4
  • Professional property host/manager
  • LGBTQIA+ friendly
  • Green Key Global
  • Fitness facilities
  • Double-glazing on all windows
  • Wheelchair accessible (may have limitations)
  • Banquet hall
  • Wheelchair accessible
  • Food and water bowls
  • Meeting rooms
  • Wheelchair-accessible registration desk
  • Spa treatment room(s)
  • Full-service spa
  • 24-hour fitness facilities
  • Yoga classes/instruction on site
  • Water-efficient showers only
  • Luggage storage
  • Porter/bellhop
  • Business center
  • 24-hour front desk
  • Number of restaurants - 1
  • Spa services on site
  • Golfing nearby
  • Smoke-free property
  • Safe-deposit box at front desk
  • Hiking/biking trails nearby
  • Conference space
  • Valet parking (surcharge)
  • Computer station
  • Wheelchair accessible path of travel
  • ATM/banking
  • Conference space size (feet) - 5000
  • 24-hour business center
  • Concierge services

Airport & Shuttle Information

8 miles from Louisville International Airport, $20 cab fare, one way

Airport Shuttle? Sorry, no airport shuttle available.

Pet Friendly?

Service animals complying with ADA Title lll regulations are allowed.

Pet max weight (per pet) in lb is 50

Pet max weight (per pet) in kg is 23

Service animals are allowed

Service animals are exempt from fees/restrictions

Pets allowed

$100 one-time non-refundable pet fee

Misc Fees / Policies

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5.00 per accommodation, per stay

We have included all charges provided to us by the property.

  • Reservations are required for massage services. Reservations can be made by contacting the hotel prior to arrival, using the contact information on the booking confirmation.
  • The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
  • Contactless check-in and contactless check-out are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Cleaning Policies

Contactless check-in is available

Contactless check-out is available

Property follows a brand or regulatory agency's sanitization guidelines ALLSAFE (Accor Hotels)

Essential workers only - NO

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